A review on non-syndromic tooth agenesis associated with PAX9 mutations
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چکیده
منابع مشابه
A review on non-syndromic tooth agenesis associated with PAX9 mutations
Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of se...
متن کاملMutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis.
Tooth agenesis in human being is the most common congenital anomaly associated with dental development. Mutations in many genes such as MSH homeobox 1 (MSX1), paired box gene 9 (PAX9), ectodysplasin A (EDA) and EDA receptor (EDAR) have been associated with familial form of this condition. However, in large majority of patients, genetic cause could not be identified. The primary aim of present s...
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Congenital Tooth Agenesis or Hypodontia is one of the most common developmental anomaly of the human dentition, presents itself with one or more missing teeth. It is a polygenetic disorder that can occur either in isolation or as a co-finding in many syndromes. The Clinical features, diagnostic characteristics and management strategies all depend on the severity of the condition, presence or ab...
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Inherited dentin defects are classified into three types of dentinogenesis imperfecta (DGI) and two types of dentin dysplasia (DD). The genetic etiology of DD-I is unknown. Defects in dentin sialophosphoprotein (DSPP) cause DD type II and DGI types II and III. DGI type I is the oral manifestation of osteogenesis imperfecta (OI), a systemic disease typically caused by defects in COL1A1 or COL1A2...
متن کاملNovel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population.
OBJECTIVES Tooth agenesis is one of the most common developmental anomalies in humans. Genetic and environmental factors may be of etiological importance in this condition. Among genes involved in tooth morphogenesis, mutations in PAX9, MSX1, AXIN2, WNT10a, and EDA genes have been associated with tooth agenesis. The aim of our study was to investigate the relationship between the PAX9 gene vari...
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ژورنال
عنوان ژورنال: Japanese Dental Science Review
سال: 2018
ISSN: 1882-7616
DOI: 10.1016/j.jdsr.2017.08.001